ISSN 1306-0015 | E-ISSN 1308-6278
Case Report
Plasmapheresis in a child with cold antibody autoimmune hemolytic anemia: case report
1 Department of Pediatrics, Division of Pediatric Hematology/Oncology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey  
2 Department of Pediatrics, Division of Pediatric Intensive Care and Infectious Diseases, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey  
Turk Pediatri Ars 2017; 52: 169-172
DOI: 10.5152/TurkPediatriArs.2017.2956
Key Words: Autoimmune hemolytic anemia, cold antibody, plasmapheresis
Abstract

Autoimmune hemolytic anemia is a picture of hemolysis which is caused by autoantibodies against red blood cell surface antigens. It is classified as primary, secondary or warm and cold autoimmune hemolytic anemia according to the temperature at which antibodies react.  It is usually an acute and self-limiting condition. Here, we present a three-year-old male patient who presented with malaise, paleness, and dark-colored urine. His hemoglobin level was 5.8 g/dL, and increased indirect bilirubin and lactate dehydrogenase levels and decreased haptoglobulin and reticulocyte levels were noted. A direct Coombs test was positive using anti-C3. Four erythrocyte suspension transfusions were given because the anemia was life-threatening. High-dose steroids (30 mg/kg/ day, methylprednisolone) and intravenous immunoglobulin (1 g/kg/day, two days) treatments were unresponsive. Plasmapheresis was performed and no further transfusions were needed after plasmapheresis. Plasmapheresis treatment can be effective in children with cold type autoimmune hemolytic anemia.

 

Cite this article as: Özdemir ZC, Bör Ö, Dinleyici EÇ, Kıral E. Plasmapheresis in a child with cold antibody autoimmune hemolytic anemia: Case report. Turk Pediatri Ars 2017; 52: 169-72.

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